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To investigate the ability to generate a therapeutic effect, the multicellular tumor spheroids were treated with Ru(II)-OH, NP2, or NP4 (10 M Ru) in a 1% or 21% O 2 atmosphere and afterward incubated with a cell live or death stain

Due to its unique mechanism of cytoplasmic precipitation, which occurs after membrane translocation, it is able to kill bacteria effectively and does not promote resistance development even after repeated use (Yang et al., 2019)

Methods: A total of 3,489 HCV patients who treated with DAAs and had achieved SVR from ten hospitals in South Korea were included in the derivation cohort

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They can detoxify cells and have both direct and indirect effects