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It is also involved in the progression from mild cognitive impairment to AD (Ansari et al., 2019)

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Regarding the therapeutic value of using CNBs in the treatment of ACD, human studies are still lacking, but studies in mice have revealed the involvement of CBRs, especially CB2R, in the inflammatory response of ACD, and possible therapies involving it have been proposed targets [57,126]

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Utilizing a large ICU cohort with detailed clinical information, we identified ACLF patients with two or more OFs according to the EASL-CLIF and NACSELD definitions