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In particular, DAS and its metabolites have been found to inhibit CYP2E1 activity in vitro (56, 57) and when administered orally at high doses to animals (58, 59)

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Specifically, 47 integrin regulates the localization of lymphocytes to the gut mucosa by binding to the gut-specific cell adhesion molecule mucosal addressin cell adhesion molecule-1 (MAdCAM-1), promoting the accumulation of immune cells at the site of inflammation, thereby exacerbating the intestinal inflammatory response [303, 304]

Hence, the amount of ibuprofen used in this study (100 mg/kg/day) would approximate to a moderate daily dose of ibuprofen in humans

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