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Scientific Reports Kraus et al

Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctions in diet-induced obese mice

Physiological activation of brown fat 3-AR through cold stress, (96-98) or direct pharmacological activation (99) rapidly activates non-shivering thermogenesis

A major advantage of MOTS-c is that it can avoid hepatotoxicity associated with metformin, AICAR, or methotrexate, which means it is a potential therapeutic target (24)