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Acyl-coenzyme A synthetase long-chain family (ACSL) 4 and lysophosphatidylcholine acyltransferase 3 are critical for ferroptosis because they promote the activation and incorporation of PUFAs into membrane lipids

The Direct Answer: glutathione vs semaglutide is not a substitution decision

GSH is transported to the ER through Sec61 via facilitated diffusion, driven by the GSH concentration gradient [37]

doi:10.1038/285017a0

This is the theoretical basis for endogenously supplied gamma-glutamylcysteines ability to raise GSH levels, as being the product of the GCL enzyme, it can be taken up by cells intact, where it feeds directly into glutathione synthase to be converted to glutathione, effectively bypassing the dysfunctional GCL