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Transcription 2010

Recently published in Nature: Cell Death and Discovery , Mahbub et al

Finally, Novotny et al

In particular, MPTP intoxication typically downregulates key autophagy regulators (LC3-II, beclin-1, parkin, PINK1), but schisandrin A treatment partially preserved the levels of these proteins, implying that it enhances autophagic clearance of toxic aggregates (59, 60)

Among them, glutathione exists in two interconvertible forms: reduced glutathione (GSH) and its oxidized disulfide (GSSG), formed by the linkage of two GSH molecules via a disulfide bond