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Additionally, in the DHE staining results, we observed that FOXO4-DRI treatment effectively reduced the ROS levels in the aorta of aged mice (Figure 2F)

BRs have been shown to be effective even in micromolar concentrations

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Indeed, microglia are crucial for the elimination of myelin debris by phagocytosis, a prerequisite for remyelination (Napoli and Neumann, 2010

VIC also stimulates iron absorption at the intestinal level by reducing Fe 3+ to Fe 2+ , making it more stable and contributing to anemia management [2,8,10]