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[71] [72] [73] Recent epidemiological findings support the process of mitohormesis, but a 2007 meta-analysis finds that in studies with a low risk of bias (randomization, blinding, follow-up), some popular antioxidant supplements (vitamin A, beta carotene, and vitamin E) may increase mortality risk (although studies more prone to bias reported the reverse)

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A pooled analysis of these two randomised-controlled trials demonstrated a placebo-adjusted reduction in OFF-time of 1 h from baseline to week 12 [143], and an open-label extension showed persistent improvement of MDS-UPDR part IV motor fluctuation subscore after 100 weeks of treatment [144, 145]

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