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Kuang, X

However, the values currently available in the literature are variable 2,21,22,23

The global incidence of lung cancer is increasing annually, with lung adenocarcinoma being the most common pathological type

Moreover, lactate produced by tumor cells may serve as a key molecule that stimulates CAFs to produce HGF through a nuclear factor-B (NF-B)-dependent mechanism [88, 142, 143], thus promoting a feed-forward pro-survival loop between tumors and TME [41]