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The primary outcome was the change in serum B12 levels, following supplemental B12 intake, allowing for a comparative evaluation of the different formulations effectiveness in increasing and maintaining B12 concentrations in the bloodstream

extreme caloric restriction may exacerbate menstrual irregularities Micronutrient optimization: Maintain adequate iron intake, particularly if experiencing heavier menstrual bleeding Contraceptive considerations: Discuss alternative contraceptive methods with your provider, as tirzepatide may affect oral contraceptive absorption For women with pre-existing menstrual irregularities or PCOS, tirzepatide treatment may ultimately improve cycle regularity as metabolic parameters normalize