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203 ZuccaP.ArgiolasA.NiedduM.PintusM.RosaA.SannaF.et al (2016)

FIGURE 2 Under the conditions of Ca 2+ influence in the concentration range of 10 7 10 4 mol/L, a dose-dependent swelling of mitochondria isolated from rat heart tissue was observed (Figure 2B)

Nat Genet 37(11):12341241

Thus, a lot of onus is on refining animal models and improving patient stratification to consider individual genetic and phenotypic variations in neurological diseases for the success of NP-based systems in clinical practice