"The adipose tissue (AT) expandability hypothesis explains that the individual capacity to appropriately store energy surplus as fat within the AT prevents the toxic deposition of lipids in other organs, such as the pancreas. Looping back to the role of the brain in obesity, I would move one level higher in the cascade of downstream effects - to the central regulation of hedonic appetite and the wiring of the reward system, overexpressed obesogenic genes within the CNS, and the role of ultra-processed food
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Thiosulfinates, particularly allicin, are thought to play an important role in the antimicrobial activity of garlic (80-82)
Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations E-GPx: extracellular glutathione peroxidase C-GPx: cellular glutathione peroxidase GPx-GI: gastrointestinal glutathione peroxidase GPx: seleniumdependent glutathione peroxidase IBD: inflammatory bowel disease DSS: dextran sodium sulfate GI: gastrointestinal t-BuOOH: tert-butyl hydroperoxide GSH: glutathione SSC: saline-sodium citrate GAPD: glyceraldehyde-3 phosphate dehydrogenase References Parks DA, Bulkley GB, Granger DN 1983 Role of oxygen-derived free radicals in digestive tract diseases
