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A recent phase I/II clinical trial exhibited no evidence of an effect on weight in obese humans, despite displaying a robust antibody response

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It will be imperative that single-unit electrophysiology approaches are used to analyze the cell-specific details of neuronal responses downstream of stimulation, but also population-level responses will have to be collected using tools such as tetrodes, array electrodes, silicone probes, or even fiber photometry and deep tissue endoscopy

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This additional loop, essential for inter-subunit communication, is located at the H-site and is involved in enzyme tetramerization and cooperativity (Liebau et al., 2009)