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In summary, although the two neurons did not die of GPX4 reduction, the study focused on only one point of GPX4 and did not delve into other regulators, indicating that there are other pathways affecting the activity of POMC neurons under obesity conditions (129)

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4 Therapeutic innovations and paradigmatic advances in traditional Chinese medicine: evidence-based insights through the gut-kidney axis framework Contemporary evidence-based medical research has unequivocally established TCM as a therapeutic modality of unprecedented sophistication in CKD managementits integrative, precision-oriented, and holistic philosophical paradigm fundamentally transcends conventional therapeutic frameworks, effectuating profound amelioration of uremic toxin homeostasis and nephroprotective mechanisms (Li et al., 2019)