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However, further detailed and comprehensive studies are needed to investigate the therapeutic effects of MEL on damage caused by ACR in other organs

Some of the right lungs were harvested and stored at -80C for subsequent analysis by real time quantitative polymerase chain reaction (qPCR) and western blotting, while other right lungs were perfused with cryomatrix (Thermo, New York, NY, United States) for immunofluorescence staining

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The amphipathic structure of melatonin allows easy access to different tissue cells and their organelles, interacting with intracellular molecules with no interaction with receptors, exerting in this way an antioxidant action

& Stonnington, H