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Whilst kidney outcomes identified in SURPASS-4 were promising [22], the true renal protective effects of tirzepatide, and indeed other GLP-1RAs, await the results of dedicated kidney outcome studies in people with established diabetic kidney disease and renal impairment that assess the risk of progressing to kidney failure as their primary endpoint

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Until these foundational biomechanics are defined, it will be premature to make predictions of concussions based Suggested Citation: "2 Neuroscience, Biomechanics, and Risks of Concussion in the Developing Brain." Institute of Medicine and National Research Council