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Description

Mechanistically, ARF represses NRF2-induced transcriptional upregulation of SLC7A11 and other antioxidant genes

L., & Andrs, V

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation

Moreover, decreased HIF-2 mRNA expression was detected in a majority of STS patient samples compared to normal adipose tissue, suggesting that EPAS1 is epigenetically silenced 38