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Description

Griendling, K

We have determined that an enlarged subsite A L , lined by a glycine-rich motif (G58, G60, G62) on the flexible TM1a helix, is the structural determinant for coordinating the bulky sulfonate group of taurine

& Huff, F

It is a dual agonist that activates both the GIP and GLP-1 receptors, and in research models this dual mechanism drives more pronounced changes in appetite signaling, gastric emptying, and glucose handling than single GLP-1 agonists