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119 CRMs are pharmacological agents or natural compounds that imitate the biochemical effects of CR by reducing the lysine acetylation rates of cellular proteins

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M2c engaged in the remodeling of the vascular structure and extracellular matrix ( Growth factors, such as vascular endothelial growth factor (VEGF) and TGF-, which promote cell proliferation and protein synthesis, are also secreted by anti-inflammatory macrophages (M2 macrophages), along with a range of protease inhibitors, proteases, and anti-inflammatory mediators ( Angiogenesis is a dynamic, managed, and regulated process, and its major drivers include proangiogenic chemicals such as fibroblast growth factor-2 (FGF-2) and VEGF, as well as anti-angiogenic compounds that affect endothelial cells