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Because we did not observe obvious differences of SLC13A3 expression between male and female human HCC tissues, we chose to use male mice for the present study

History of Alcohol Withdrawal Withdrawal from alcohol is nothing new

Acknowledgements The authors research is funded by Instituto de Salud Carlos III (ISCIII)-Fondo de Investigacion Sanitaria (FIS)-Fondo Europeo de Desarrollo Regional FEDER (grants PI18/01366, PI21/00251, PI19/00588, P21/01453, PI18/01133, PI19/00815, PI22/00469, PI22/00050), European Research Area PerMed JTC2018 (KIDNEY ATTACK AC18/00064) and the RICORS programme to RICORS2040 (RD21/0005/0001), and also by Comunidad de Madrid en Biomedicina (grant P2022/BMD-7223, CIFRA_COR-CM)

NRF2 target genes also involve PPP products such as G6PD, 6PGD, transketolase, and transaldolase, indicating that NRF2 activation is crucial for participating in and/or maintaining the PPP, especially for producing NADPH to fuel FAS, TRX, and GSH systems 172

Available safety data suggest that S-acetyl glutathione has a favorable safety profile when consumed appropriately.