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To further characterize this mechanism, we coupled deep mutational scanning (DMS) of CRBN to a fluorescence-activated cell sorting (FACS)-based assessment of ENL degradation in the presence of rac -dHTC1 or the ENL PROTAC, SR-1114 (Extended Data Fig

These parameters together define the hydrogels viscoelastic behavior ( In the study by Peptide sequence modifications also impact rheology: substituting valine with less hydrophobic residues like alanine or serine reduces gel stiffness and resilience ( The SAPs rheology is affected, not only by intrinsic characteristics of the material, but also by the external physico-chemical conditions, that can influence the peptide secondary structure

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K.WadhwaS.GulatiM.VishwasS.KhursheedR.PaudelK