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Frias JP, Bastyr EJ, Vignati L, Tschp MH, Schmitt C, Owen K, et al

Using in vivo electrophysiology and behavioral assays in mice, we found that: Psilocybin inhibited serotonin neuron firing via 5-HT2A receptors and induced the head twitch response (HTR), consistent with psychedelic-like activity