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Wistar albino rats (pre-treated with methotrexate to produce folate deficiency similar to in humans exposed to methanol) then exposed to aspartame (40 mg/kg) showed a marked increase in the TNF gene expression and a decrease in NF-B gene expression in the liver relative to the liver of unexposed study controls ( P 0.05) (Rahiman and Pool, 2014)

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Theres little research on phospholipid synthesis in TC, but it has early been proved that in rat thyroid tumor line 1-5G, phospholipid levels are 50% lower than normal, in response to thyrotropin (TSH) stimulation and receptor upregulation [140]