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Further study (103) has revealed that its anti-inflammatory and immunomodulatory effects may be related to the inhibition of the activation of MAPK signaling pathways (JNK, ERK1/2 and p38)

References: Pickart L, Margolina A

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Generally, it happens in conditions with low blood flow to the liver resulting in insufficient perfusion such as liver resections and transplantation (83), cardiogenic and hemorrhagic shock, surgical cutting, cardiovascular or laparoscopic surgery and abdominal compartment syndromes (84, 85)