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Like methionine, it can contribute to mild GI discomfort at higher doses in some individuals

The other is a broader signaling actor

These include anemia, neurological issues, and a higher risk of heart disease

These subgroup analyses are shown in Table 12 and Figure 3 and Figure 4

one or more NNMT inhibitors such as a cation of Formula I or IA, or otherwise disclosed herein one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy