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The uptake of peptides 26 and 27 is only slightly less compared to peptide 22 even though these peptides have a substitution of a positively charged residue (K) for Q9 or N10 as opposed to negatively charged residue (E) for Q9 in peptide 22 (Fig

GSTs were first recognized as enzymes inactivating xenobiotics, in particular electrophilic mutagens and carcinogens, leading to their excretion as mercapturic acids (Mannervik, 1985

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Understanding the mechanisms behind these responses can help researchers interpret observations more confidently

Additionally, any newly identified drug lead has to pass the acid test of pre-clinical efficacy, safety, and compatibility with the existing first-line and second-line drugs