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[DOI] [PMC free article] [PubMed] 103.Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HAW

In oxygen-rich regions, LDHB catalysis in oxidative cancer cells results in the conversion of lactate to pyruvate, which then enters the TCA cycle together with NADH via the malateaspartate shuttle

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Additionally, this can cause astrocytic swelling, which leads to channel opening that has been associated with astrocytic release of glutamate, which would further support excitotoxicity (Kimelberg et al., 1990)

Given its strong association with favorable treatment response and prolonged survival, integrating the 1p/19q codeletion status into routine GBM management enhances personalized treatment planning and improves patient outcomes