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After significantly scavenging endogenous ROS via exerting antioxidant activities, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and total antioxidant capacity, GSH-CDs with good biocompatibility have been demonstrated to effectively improve mitochondrial dysfunction and rescue NPCs from senescence, catabolism, and inflammatory factors in vivo and in vitro

This observation nevertheless has to be taken with caution given that this effect could have been influenced by other factors, such as disease severity or concomitant medication

While levodopa is the most effective drug, it has its limitations: over time, the response to treatment decreases, and increasing the dose becomes necessary

Rats neurotransmitters, including acetylcholine (Ach), acetylcholinesterase (AchE), GABA, serotonin or 5-hydroxytryptamine (5-HT), and dopamine ELISA kits were obtained from Chongqing Biospes Co

A total of 66,433 (39.05%) unigenes were annotated in at least one databases, and the detailed annotation information and the distributions of functional categories in GO and KEGG databases were listed and displayed in Supplementary Table 3 and Supplementary Figure 1, respectively