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While melanoma cells metastasizing through the blood are reportedly dependent on ferroptosis, lymph, on the other hand, experiences lower levels of oxidative stress and protects metastatic cells from ferroptosis, thereby increasing their capacity to endure during metastatic events through the blood (Ubellacker et al

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Molecular glues are a class of small molecules that can induce or stabilize a novel proteinprotein interaction interface, thereby gluing the target protein to an E3 ligase and facilitating its degradation [316]