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Sustained-release, extended-release, and other time-release formulations in neuropsychiatry

Different delivery methods are used depending on the target area

Predrag Sikiric (Medische Faculteit Zagreb, 1991 ) Meest gebruikte experimentele dosering in dierstudies: 10 g/kg intraperitoneaal of oraal, dagelijks Standaard doelwitroutes: VEGFR2 -angiogenese, NO-synthase , 5-HT2A -serotoninereceptor, dopamine D2 -receptor Klinisch programma in Kroati gestaakt in Phase 2 (ziekte van Crohn) WADA Prohibited List: opgenomen in 2022 in categorie S0 (Non-Approved Substances) Referentiebronnen (PubMed) Sikiric P

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The long latent period between the injection of a potential carcinogen and the appearance of a tumor makes it impossible to measure accurately the risk in man