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AJs establish cell-cell contacts, which are essential for TJs maturation and maintenance

Activated by bile acid in the gut, FXR induces the expression of fibroblast growth factor 15 (FGF15), which is secreted into the liver via the portal system to activate liver FXR, thus regulating the expression of genes governing enterohepatic bile acid homeostasis

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Additionally, some peptide users may experience increased fluid retention, leading to a puffy appearance and aggravating conditions like hypertension

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