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Silymarin suppresses hepatic stellate cell activation in a dietary rat model of nonalcoholic steatohepatitis: analysis of isolated hepatic stellate cells

The acetyl-CoA typically enters the TCA cycle for ATP production

Booth, J

Different reactive oxygen species (ROS) generators contribute to NAFLD inflammatory and fibrotic progression, which is quite strictly linked to the lipotoxic liver injury from fatty acids and/or a wide variety of their biologically active metabolites in the context of either a two-hit or a (more recent) multiple parallel hits theory