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Semaglutide causes nausea through two primary mechanisms involving GLP-1 receptor activation

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In the Cagrilintide groups, observed mean weight losses ranged from 5.0% to 9.8% at week 32, slightly less than the 6.1% to 10.8% observed at week 26

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In another study, an 84-week open-label trial with about 800 participants, people taking CagriSema had an average of 23% weight loss versus about 25 to 26% for tirzepatide (Zepbound) at the highest dose