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Leslie EM (2012) Arsenicglutathione conjugate transport by the human multidrug resistance proteins (MRPs/ABCCs)

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2.5 Dosage Modification of Ibuprofen in Patients with Mild to Moderate Renal Impairment Receiving Pemetrexed for injection In patients with creatinine clearances between 45 mL/min and 79 mL/min, modify administration of ibuprofen as follows [see Warnings and Precautions (5.6), Drug Interactions (7) and Clinical Pharmacology (12.3)]: Avoid administration of ibuprofen for 2 days before, the day of, and 2 days following administration of pemetrexed for injection

Our in vitro data demonstrates the dysregulation of lipid metabolism in BWS-hepatocytes, which coincided with observed upregulation of PPARA during hepatocyte differentiation