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These mechanistic findings, together with the excellent safety profile after methanol and ethylene glycol poisoning and after an APAP overdose, suggest that fomepizole may be a promising antidote against APAP overdose that could be useful as adjunct treatment to NAC

IV therapy circumvents this entire process, delivering vital nutrients directly to the cells that need them most

Not recommended for pregnant, breastfeeding or menopausal women

4.1.1 Local delivery of RNA-LNPs A straightforward way to bypass hepatic accumulation of LNPs is to change the administration route from intravenous delivery to other administration routes, which could shorten the delivery path and enhance accessibility to the target cells (Figure 3) (Chenthamara et al., 2019