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Piperazine Erastin (PE) increases polarity and water compatibility, raising aqueous solubility by more than an order of magnitude relative to Erastin and improving exposure and metabolic stability (78, 79)

(b) cardiac abnormalities consisting of atrioventricular conduction defects, tachyarrhythmia, low ejection fraction, and dilated cardiomyopathy (either due to the disease itself or, more often, to hypertension or fluid retention associated with long-term steroid use)