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In contrast, the role of eosinophils in chronic cutaneous inflammations including infections remains poorly understood and requires further investigation, considering the barrier and antimicrobial function of the skin (Coates et al, 2018)

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The CRC with PLA cohort had a higher Charlson Comorbidity Index (88% had CCI of 3 or above vs 78.42% in the CRC without PLA cohort, p=0.00)

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However, this cannot guarantee that all enrolled patients definitely have CNV secondary to AMD and is a limitation