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Key Areas of Research The existing body of preclinical literature on BPC-157 spans several key areas: Tissue repair mechanisms Multiple animal model studies have investigated BPC-157's role in connective tissue, muscle, and tendon repair pathways, with results suggesting it may upregulate growth factor expression including VEGF and FGF

The crucial role played by the TGF- pathway is demonstrated by a mouse model in which the TGF- pathway is suppressed via the deletion of the high-affinity type II TGF receptor in resident fibroblasts

Neuron 89 , 683694 (2016)

Alpha-lipoic acid activates AMPK to protect against oxidative stress and apoptosis in rats with diabetic peripheral neuropathy

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