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[Abstract]2024 May:223:116194

25 In Parkinsons Disease (PD), Acetyl-l-carnitine is a precursor to glutathione, increases dopamine transporter density, and in PD patients has shown corresponding improvements in clinical outcomes

In a scopolamine-induced cognitive impairment model in rats, Dihexa administered intracerebroventricularly (0.1 to 1.0 nmol), intraperitoneally (up to 0.5 mg/kg/day), or orally (up to 2.0 mg/kg/day) significantly improved performance on the Morris water maze (reduced latency to locate the hidden platform and increased time spent in the target quadrant during probe trials) compared with scopolamine-treated, Dihexa-untreated animals, with the highest doses producing performance indistinguishable from non-impaired controls

Statistical significance analyses were performed on data obtained from at least 3 experiments and 3 technical replicates

10.3390/ijms232213886 269 WangY.WangM.FanK.LiT.YanT.WuB.et al (2018b)