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Impairment of SELENOS is directly associated with increased cellular cytokine production and release (Reference Curran, Jowett and Elliott65)

doi: 10.1007/s00018-002-8520-9 49 BabiorBLambethJNauseefW

Oxidative stress causes cellular damage and accelerates neuro-degeneration by inducing the reactive oxygen species (ROS) that oxidize vital cellular components such as lipids, proteins and DNA [41, 42]