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Moisture can lead to peptide hydrolysis and degradation

doi: 10.1182/blood-2021-148387 35 El HasbaniGMusallamKMUthmanICappelliniMDTaherAT

doi: 10.1016/j.tcb.2019.02.004, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Wong Y

Specifically, a high-fat and high-sugar diet increased the -amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid to N-methyl-D-aspartic acid receptor current ratio in medium spiny neurons and prolonged spontaneous glutamate-mediated currents, increased DA release and slower DA reuptake in the striatum, and reduced MOR-mediated synaptic plasticity (73)