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In the presence of peroxyl radicals, CoQ10 (ubiquinone) state becomes less reactive than the CoQ10 (ubiquinol) form

Besides the protective role against oxidative stress, selenium appears to exert pro-anabolic effects to augment the regeneration capacity of cartilage

Moreover, GPX3 plays a pivotal role in ABA-mediated stress signaling by interacting with phosphatases ABI1 and ABI2, key regulators of this pathway ( Figure 5 )

This, leads to a decrease in Akt phosphorylation downstream which causes an activation of apoptosis associated pathways of caspase 3 and caspase 7 [115]

doi: 10.1111/ijfs.12749 70 Jara-QuijadaEPrez-WonMTabilo-MunizagaGLemus-MondacaRGonzlez-CavieresLPalma-AcevedoAet al