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Abstract Down syndrome (DS), the most frequent chromosomic aberration, results from the presence of an extra copy of chromosome 21

This side-on association is energetically less favorable and fails to position the hydrophobic loop in the configuration

doi: 10.1210/edrv.19.5.0349 149 DuckworthWCRunyanKRWrightRKHalbanPASolomonSS

This will reduce the amount of drug that reaches the general circulation but will not affect the rate of absorption, which is usually determined by lipid solubility