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Administrated resveratrol positively affects the synthesis of sirtuins, SIRT1 (a family of proteins NAD + -dependent histone deacetylases playing an important role in the regulation of metabolic pathways, see below) activating then superoxide dismutase 2 (Mn-SOD) expression in cardiomyocytes and improved cardiac functions (Tanno et al

Scientific researchers theorize that one way to explain aging relates to the harmful impact of free radicals called oxidants

Those claims often sound more certain than the evidence allows

Nat Commun 8 , 16087 (2017)

It is also found in many foods, including spinach and avocados, but is poorly absorbed by the body when consumed orally