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Salek RM, Maguire ML, Bentley E, Rubtsov DV, Hough T, Cheeseman M, Nunez D, Sweatman BC, Haselden JN, Cox RD, Connor SC, Griffin JL (2007) A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human

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Or, the glutamate can be further converted to GABA using the GAD1 enzyme, which requires the active form of vitamin B6 (P5P) as a cofactor.[ref] Genetic variants that reduce the conversion of B6 to its active form, P5P, could therefore impact GABA synthesis and GABAergic neurons