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Indeed, combination of exome, transcriptome, and metabolome analyses of multiple NSCLC cell lines also clearly demonstrated that remarkable enhancement of glutamate excretion, cystine uptake, and glutathione synthesis is a striking and reproducible feature of NRF2-addicted cancer cells (Saigusa et al

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19 The pharmacologic significance of the mononuclear phagocyte system reflects their role in inflammation (Figure 20-3

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Of note, GSTO1 was identified as one of the cellular targets of locostatin, an oxazolidinone-based cell migration inhibitor, although its role in cell migration has not been well characterized 42