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2.2.3 Regulatory role of intestinal excretion Quantitative contribution: Using C14 tracer studies, Sorensen (1965) demonstrated that a significant portion of total body uric acid turnover (1/3) is excreted via the intestine (extrarenal elimination pathway) compared to 2/3 excreted renally (Du et al., 2024)

The central components include: (i) the paraventricular nuclei (PVN) of the hypothalamus, which secrete corticotropin-releasing hormone (CRH and arginine vasopressin (AVP)

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9,11 Many biochemical studies have been performed in murine models