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If these agents are used with ribavirin, treated patients should be carefully monitored for potential problems

For peptide nucleic acids (PNAs), the sugar-phosphate backbone is replaced by a peptide backbone, which retains the specific binding ability with DNA/RNA and offers higher affinity and better stability than natural nucleic acids

patients with more adipose tissue at the injection site do not need a longer needle, since subcutaneous tissue is typically reached within the first few millimeters of insertion

The nodular configuration of smooth muscle fascicles helps make the diagnosis of leiomyoma

459,460 However, covalent conjugation also has drawbacks