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doi: 10.1021/jf050264a

Human trials have predominantly used topical or brief systemic dosing, and tolerability is overall reported to be good

Peroxynitrite inhibition of Coxsackievirus infection by prevention of viral RNA entry

By crossing a mouse model of DS (the Tc1 mouse) that does not have an additional copy of APP to a transgenic mouse overexpressing APP with AD-causing mutations (J20 mouse), the additional copy of Hsa21, independent of an extra copy of APP , exacerbated A aggregation and deposition, enhanced APP transgene-associated mortality, altered behavior, and reduced cognitive performance in double-mutant progeny that model DSAD (477)

Medley JK, Persons J, Biswas T, Olsen L, Peu R, Krishnan J, Rohner N (2022) The metabolome of Mexican cavefish shows a convergent signature highlighting sugar, antioxidant, and ageing-related metabolites