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By blocking NNMT, it prevents the methylation reaction that depletes SAM and nicotinamide, thereby preserving both cofactors and restoring the metabolic machinery that NNMT overexpression had suppressed

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Our results revealed that oxidative stress-related pathways, including glutathione (GSH) metabolism, were significantly enriched in the auditory cortex of mice exhibiting tinnitus-like behavior

[DOI] [PubMed] [Google Scholar] 79.Guo A., Srinath J., Feuerecker M., Crucian B., Briegel J., Boulesteix A.L., Kaufmann I., Chouker A